Anyone who is at all unable to travel as much as the next person who can might consider themselves at a disadvantage insofar as they simply don’t catch as much.
Myself, for example, with a knee that operates only at about 25% efficiency right now and causes me pain every day (sometimes excruciatingly so) means I don’t go “hunting”. I have four 10-15 minutes walks each day to work and back: one to start work, one to cone home from it, and both again for lunch to take care of my pets at midday. I can’t be bothered to put up with the discomfort to do more than that.
Even so, I’ve amassed a nice collection:
And have done (what I feel is) relatively well in arenas:
I’ve bought 4 lower-priced one-time offers, 3 for actual money and 1 for in-game cash, and nothing regularly-priced.
You’ll note that my arena team still uses 3 commons, and all three have been arguably better than my epics so I’m inclined to say that, so long as you get the occasional or even frequent spawns at your house, you’ll still do just fine in arenas and the rest of it is more or less as Paytolose suggested: make your own enjoyment out of it.